| 1. Round | 29/08/2010 | Ergotelis | - | Asteras Tripolis | 0:1 | ||||
| 2. Round | 11/09/2010 | Asteras Tripolis | - | PAOK Saloniki | 0:0 | ||||
| 3. Round | 19/09/2010 | AEK Athen | - | Asteras Tripolis | 2:2 |  |
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| 4. Round | 25/09/2010 | Olympiakos Piraeus | - | Asteras Tripolis | 3:0 | |
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| 5. Round | 02/10/2010 | Asteras Tripolis | - | Atromitos | 1:1 | ||||
| 6. Round | 17/10/2010 | AE Lárissa | - | Asteras Tripolis | 0:2 | ||||
| 7. Round | 23/10/2010 | Asteras Tripolis | - | Iraklis Saloniki | 0:0 | ||||
| 8. Round | 31/10/2010 | AO Kerkyra | - | Asteras Tripolis | 1:2 | ||||
| 9. Round | 06/11/2010 | Asteras Tripolis | - | Panserraikos | 0:2 | ||||
| 10. Round | 15/11/2010 | Asteras Tripolis | - | AO Kavala | 0:1 | ||||
| 11. Round | 20/11/2010 | Olympiakos Volou | - | Asteras Tripolis | 1:1 | ||||
| 12. Round | 28/11/2010 | Asteras Tripolis | - | Skoda Xanthi | 1:2 | ||||
| 13. Round | 05/12/2010 | Aris Saloniki | - | Asteras Tripolis | 1:0 | |
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| 14. Round | 12/12/2010 | Asteras Tripolis | - | Panathinaikos | 0:0 | ||||
| 15. Round | 18/12/2010 | Panionios GSS | - | Asteras Tripolis | 0:0 | ||||
| 25. Round | 06/03/2011 | AO Kavala | - | Asteras Tripolis | 1:0 | ||||
| 29. Round | 10/04/2011 | Panathinaikos | - | Asteras Tripolis | 1:0 |  |
France