| Group 5 | 21/02/2008 | CF América | - | Universidad Católica | 2:1 |  |
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| Group 5 | 27/02/2008 | River Plate | - | CF América | 2:1 | |
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| Group 5 | 14/03/2008 | CF América | - | Universidad San Martín | 3:1 | |
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| Group 5 | 27/03/2008 | Universidad San Martín | - | CF América | 1:0 | ||||
| Group 5 | 03/04/2008 | CF América | - | River Plate | 4:3 | |
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| Group 5 | 18/04/2008 | Universidad Católica | - | CF América | 2:0 | ||||
| Round of 16 | 30/04/2008 | CF América | - | Flamengo RJ | 2:4 | ||||
| Round of 16 | 08/05/2008 | Flamengo RJ | - | CF América | 0:3 | |
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| Quarter-finals | 16/05/2008 | CF América | - | Santos FC | 2:0 | |
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| Quarter-finals | 23/05/2008 | Santos FC | - | CF América | 1:0 |  |
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| Semi-finals | 28/05/2008 | CF América | - | LDU Quito | 1:1 | ||||
| Semi-finals | 04/06/2008 | LDU Quito | - | CF América | 0:0 |
Paraguay