| 1. Round | 05/07/2024 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 2. Round | 14/07/2024 | Santos Laguna | - | Pumas UNAM | 1:1 |  |
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| 3. Round | 17/07/2024 | Atlas Guadalajara | - | Santos Laguna | 1:0 | ||||
| 4. Round | 21/07/2024 | Santos Laguna | - | UANL Tigres | 0:3 | ||||
| 8. Round | 19/08/2024 | Club Tijuana | - | Santos Laguna | 3:1 | |
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| 5. Round | 25/08/2024 | Club León | - | Santos Laguna | 1:1 | ||||
| 9. Round | 23/09/2024 | Santos Laguna | - | Deportivo Toluca | 2:0 | ||||
| 10. Round | 29/09/2024 | Atlético San Luis | - | Santos Laguna | 3:1 | ||||
| 11. Round | 07/10/2024 | Santos Laguna | - | FC Juárez | 0:2 | ||||
| 12. Round | 20/10/2024 | CF América | - | Santos Laguna | 3:0 | ||||
| 13. Round | 23/10/2024 | Santos Laguna | - | CF Pachuca | 1:1 | |
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| 14. Round | 26/10/2024 | Santos Laguna | - | Mazatlán FC | 0:0 | ||||
| 15. Round | 03/11/2024 | Cruz Azul | - | Santos Laguna | 2:0 | |
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| 16. Round | 06/11/2024 | Santos Laguna | - | Deportivo Guadalajara | 0:2 | ||||
| 17. Round | 09/11/2024 | Gallos Blancos | - | Santos Laguna | 3:2 |
Mexico