| 1. Round | 23/02/2025 | Nashville SC | - | New England Revolution | 0:0 | ||||
| 2. Round | 02/03/2025 | New York RB | - | Nashville SC | 2:0 | ||||
| 3. Round | 09/03/2025 | Nashville SC | - | Portland Timbers | 2:0 | ||||
| 4. Round | 16/03/2025 | Philadelphia Union | - | Nashville SC | 1:3 |  |
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| 5. Round | 23/03/2025 | Nashville SC | - | CF Montréal | 3:0 | ||||
| 6. Round | 30/03/2025 | Nashville SC | - | FC Cincinnati | 1:2 | ||||
| 7. Round | 05/04/2025 | Charlotte FC | - | Nashville SC | 2:1 | ||||
| 8. Round | 13/04/2025 | Nashville SC | - | Real Salt Lake | 2:1 | |
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| 9. Round | 20/04/2025 | Seattle Sounders | - | Nashville SC | 3:0 | ||||
| 10. Round | 27/04/2025 | Nashville SC | - | Chicago Fire | 7:2 | |
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| 11. Round | 03/05/2025 | Atlanta United FC | - | Nashville SC | 1:1 | ||||
| 12. Round | 11/05/2025 | Nashville SC | - | Charlotte FC | 2:1 | ||||
| 13. Round | 15/05/2025 | Nashville SC | - | New York RB | 2:1 |  |
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| 14. Round | 18/05/2025 | Nashville SC | - | D.C. United | 0:0 | |
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| 15. Round | 25/05/2025 | Toronto FC | - | Nashville SC | 1:2 | |
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| 16. Round | 29/05/2025 | Columbus Crew | - | Nashville SC | 2:2 | |
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| 17. Round | 31/05/2025 | Nashville SC | - | New York City FC | 2:2 | |
England