| 1. Round | 24/07/2022 | KV Mechelen | - | Royal Antwerp FC | 0:2 | ||||
| 2. Round | 31/07/2022 | Royal Antwerp FC | - | SV Zulte Waregem | 1:0 | ||||
| 3. Round | 07/08/2022 | Royal Antwerp FC | - | Oud-Heverlee Leuven | 4:2 | ||||
| 4. Round | 14/08/2022 | KAS Eupen | - | Royal Antwerp FC | 0:1 | ||||
| 6. Round | 28/08/2022 | KAA Gent | - | Royal Antwerp FC | 1:2 | ||||
| 5. Round | 31/08/2022 | Royal Antwerp FC | - | Union Saint-Gilloise | 4:2 |  |
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| 7. Round | 04/09/2022 | Royal Antwerp FC | - | KVC Westerlo | 3:0 | ||||
| 8. Round | 11/09/2022 | Cercle Brugge | - | Royal Antwerp FC | 0:2 |  |
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| 9. Round | 16/09/2022 | Royal Antwerp FC | - | RFC Seraing | 2:1 | ||||
| 10. Round | 02/10/2022 | KV Kortrijk | - | Royal Antwerp FC | 2:1 | ||||
| 11. Round | 07/10/2022 | Royal Antwerp FC | - | Sint-Truidense VV | 2:0 | ||||
| 12. Round | 16/10/2022 | Standard Liège | - | Royal Antwerp FC | 3:0 | ||||
| 13. Round | 20/10/2022 | Royal Antwerp FC | - | KV Oostende | 3:0 | ||||
| 14. Round | 23/10/2022 | Royal Antwerp FC | - | KRC Genk | 1:3 | ||||
| 15. Round | 30/10/2022 | Sporting Charleroi | - | Royal Antwerp FC | 1:0 |
USA