| 2. Round | 03/05/2021 | Vancouver Whitecaps | - | Colorado Rapids | 0:1 | ||||
| 2. Round | 09/05/2021 | Colorado Rapids | - | Minnesota United FC | 3:2 |  |
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| 2. Round | 16/05/2021 | Colorado Rapids | - | Houston Dynamo | 3:1 |  |
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| 2. Round | 23/05/2021 | Los Angeles FC | - | Colorado Rapids | 2:1 | ||||
| 2. Round | 30/05/2021 | Colorado Rapids | - | FC Dallas | 3:0 | ||||
| 3. Round | 20/06/2021 | FC Cincinnati | - | Colorado Rapids | 0:2 | ||||
| 3. Round | 24/06/2021 | Sporting Kansas City | - | Colorado Rapids | 3:1 | ||||
| 4. Round | 05/07/2021 | Colorado Rapids | - | Seattle Sounders | 1:1 |
USA