1. Round | 25/07/2021 | MŠK Žilina | - | ŠKF Sereď | 3:0 | ||||
2. Round | 01/08/2021 | Zlaté Moravce | - | MŠK Žilina | 0:1 | ||||
6. Round | 29/08/2021 | Spartak Trnava | - | MŠK Žilina | 1:1 | ||||
7. Round | 11/09/2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
8. Round | 19/09/2021 | Slovan Bratislava | - | MŠK Žilina | 2:2 | ||||
9. Round | 25/09/2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
10. Round | 02/10/2021 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 | ||||
11. Round | 16/10/2021 | MŠK Žilina | - | FC DAC 1904 | 0:2 | ||||
12. Round | 22/10/2021 | ŠKF Sereď | - | MŠK Žilina | 1:1 | ||||
15. Round | 20/11/2021 | MŠK Žilina | - | Tatran Liptovský Mikuláš | 2:2 | ||||
16. Round | 30/11/2021 | FK Senica | - | MŠK Žilina | 2:2 | ||||
22. Round | 26/02/2022 | FC DAC 1904 | - | MŠK Žilina | 3:1 |