| 1. Round | 01/07/2021 | FC Floreşti | - | CS Petrocub | 0:1 | ||||
| 2. Round | 17/07/2021 | FC Zimbru | - | FC Floreşti | 4:0 |  |
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| 3. Round | 24/07/2021 | FC Floreşti | - | Dinamo-Auto | 0:1 | ||||
| 4. Round | 31/07/2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 5. Round | 08/08/2021 | FC Milsami | - | FC Floreşti | 4:1 | ||||
| 6. Round | 15/08/2021 | FC Floreşti | - | FC Sfîntul Gheorghe | 1:5 | ||||
| 8. Round | 25/08/2021 | CS Petrocub | - | FC Floreşti | 2:0 | ||||
| 9. Round | 11/09/2021 | FC Floreşti | - | FC Zimbru | 1:3 | ||||
| 10. Round | 18/09/2021 | Dinamo-Auto | - | FC Floreşti | 1:0 | ||||
| 11. Round | 22/09/2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Round | 26/09/2021 | FC Floreşti | - | FC Milsami | 0:3 | ||||
| 13. Round | 01/10/2021 | FC Sfîntul Gheorghe | - | FC Floreşti | 4:1 | |
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| 14. Round | 16/10/2021 | FC Floreşti | - | FC Bălţi | 1:3 | ||||
| 15. Round | 23/10/2021 | FC Floreşti | - | CS Petrocub | 3:4 | ||||
| 16. Round | 30/10/2021 | FC Zimbru | - | FC Floreşti | 3:0 | ||||
| 17. Round | 06/11/2021 | FC Floreşti | - | Dinamo-Auto | 1:5 | ||||
| 18. Round | 20/11/2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 19. Round | 28/11/2021 | FC Milsami | - | FC Floreşti | 5:0 |
Moldova