| 1. Round | 08/01/2022 | Gallos Blancos [] | - | CF América [] | 0:4 | ||||
| 4. Round | 29/01/2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 7. Round | 19/02/2022 | CF América [] | - | Club Necaxa [] | 3:3 | ||||
| 8. Round | 26/02/2022 | CF América [] | - | Deportivo Toluca [] | 1:2 | ||||
| 9. Round | 05/03/2022 | Cruz Azul [] | - | CF América [] | 3:1 |
Mexico