| 4. Round | 28/02/2022 | River Plate | - | Cerrito | 3:1 | ||||
| 5. Round | 05/03/2022 | River Plate | - | Cerro Largo | 1:1 |  |
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| 6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Round | 03/04/2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Round | 10/04/2022 | River Plate | - | Albion | 4:1 | ||||
| 9. Round | 17/04/2022 | Nacional | - | River Plate | 1:1 | ||||
| 10. Round | 23/04/2022 | River Plate | - | Danubio | 0:0 | ||||
| 11. Round | 07/05/2022 | Deportivo Maldonado | - | River Plate | 2:1 | ||||
| 14. Round | 29/05/2022 | River Plate | - | Peñarol | 0:0 | |
Uruguay
Italy