| 1. Round | 12/01/2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 7. Round | 15/02/2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 9. Round | 20/02/2025 | Santos Laguna | - | Cruz Azul | 0:1 | ||||
| 8. Round | 23/02/2025 | Santos Laguna | - | Atlas Guadalajara | 2:0 | ||||
| 10. Round | 03/03/2025 | CF Monterrey | - | Santos Laguna | 4:2 | ||||
| 11. Round | 09/03/2025 | Santos Laguna | - | Club León | 2:1 | ||||
| 12. Round | 15/03/2025 | UANL Tigres | - | Santos Laguna | 3:0 | ||||
| 13. Round | 31/03/2025 | Santos Laguna | - | Atlético San Luis | 2:3 | ||||
| 14. Round | 07/04/2025 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 15. Round | 14/04/2025 | Santos Laguna | - | Gallos Blancos | 1:2 | ||||
| 16. Round | 17/04/2025 | Pumas UNAM | - | Santos Laguna | 2:0 |  |
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| 17. Round | 21/04/2025 | Santos Laguna | - | Club Tijuana | 0:4 |
USA
Mexico