| 1. Round | 13/01/2021 | Pumas Tabasco | - | Tapatío | 0:1 | ||||
| 2. Round | 21/01/2021 | Club Celaya | - | Pumas Tabasco | 2:1 | ||||
| 3. Round | 27/01/2021 | Mineros de Zacatecas | - | Pumas Tabasco | 1:2 | ||||
| 7. Round | 26/02/2021 | Tepatitlán | - | Pumas Tabasco | 1:2 | ||||
| 8. Round | 04/03/2021 | Pumas Tabasco | - | Atlético Morelia | 0:1 | ||||
| 9. Round | 10/03/2021 | Dorados de Sinaloa | - | Pumas Tabasco | 1:1 | ||||
| 10. Round | 17/03/2021 | Pumas Tabasco | - | TM Fútbol Club | 0:0 | ||||
| 11. Round | 23/03/2021 | Coyotes de Tlaxcala | - | Pumas Tabasco | 2:3 | ||||
| 12. Round | 27/03/2021 | Pumas Tabasco | - | Venados FC | 0:2 | ||||
| 15. Round | 15/04/2021 | Pumas Tabasco | - | Cancún FC | 1:2 |
Mexico