| 2. Round | 15/08/2021 | Swift Hesperange | - | Union Titus Pétange | 0:2 |  |
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| 3. Round | 23/08/2021 | Union Titus Pétange | - | FC Rodange 91 | 3:0 | ||||
| 9. Round | 17/10/2021 | Union Titus Pétange | - | RFCU Luxemburg | 4:2 | ||||
| 10. Round | 23/10/2021 | Progrès Niedercorn | - | Union Titus Pétange | 3:2 | ||||
| 11. Round | 07/11/2021 | US Mondorf | - | Union Titus Pétange | 2:1 | ||||
| 12. Round | 21/11/2021 | Union Titus Pétange | - | Etzella Ettelbruck | 4:1 | |
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| 14. Round | 05/12/2021 | Union Titus Pétange | - | Victoria Rosport | 0:3 | ||||
| 18. Round | 20/02/2022 | Union Titus Pétange | - | RM Hamm Benfica | 3:1 | ||||
| 19. Round | 27/02/2022 | FC Wiltz 71 | - | Union Titus Pétange | 3:2 | ||||
| 21. Round | 13/03/2022 | Jeunesse Esch | - | Union Titus Pétange | 1:0 | ||||
| 22. Round | 19/03/2022 | Union Titus Pétange | - | US Hostert | 3:0 | |
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| 24. Round | 10/04/2022 | Union Titus Pétange | - | Progrès Niedercorn | 0:0 | ||||
| 25. Round | 16/04/2022 | Union Titus Pétange | - | US Mondorf | 1:1 | ||||
| 26. Round | 24/04/2022 | Etzella Ettelbruck | - | Union Titus Pétange | 0:1 | ||||
| 27. Round | 01/05/2022 | Union Titus Pétange | - | FC Differdange 03 | 1:2 |
Germany