| 1. Round | 05/09/2020 | FC Gießen | - | FC 08 Homburg | 1:2 | ||||
| 3. Round | 12/09/2020 | FC Gießen | - | Rot-Weiß Koblenz | 3:2 | ||||
| 4. Round | 19/09/2020 | FSV Frankfurt | - | FC Gießen | 1:0 | ||||
| 8. Round | 10/10/2020 | Bahlinger SC | - | FC Gießen | 3:1 |  |
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| 9. Round | 17/10/2020 | FC Gießen | - | SG Sonnenhof Großaspach | 1:1 |  |
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| 10. Round | 20/10/2020 | Kickers Offenbach | - | FC Gießen | 1:0 | |
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| 11. Round | 24/10/2020 | FC Gießen | - | 1899 Hoffenheim II | 1:2 | |
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| 6. Round | 27/10/2020 | VfR Aalen | - | FC Gießen | 1:0 | ||||
| 12. Round | 30/10/2020 | TSG Balingen | - | FC Gießen | 1:1 | ||||
| 24. Round | 20/02/2021 | Rot-Weiß Koblenz | - | FC Gießen | 1:1 | ||||
| 25. Round | 27/02/2021 | FC Gießen | - | FSV Frankfurt | 0:1 | ||||
| 34. Round | 24/04/2021 | TSV Steinbach Haiger | - | FC Gießen | 4:0 | ||||
| 35. Round | 01/05/2021 | FC Gießen | - | SC Freiburg II | 1:2 | ||||
| 36. Round | 04/05/2021 | Bayern Alzenau | - | FC Gießen | 1:1 | ||||
| 37. Round | 08/05/2021 | FC Gießen | - | SSV Ulm 1846 | 1:2 | ||||
| 38. Round | 15/05/2021 | FC Gießen | - | FK Pirmasens | 1:0 | ||||
| 39. Round | 22/05/2021 | VfB Stuttgart II | - | FC Gießen | 1:1 |
Germany