| 1. Round | 08/01/2023 | Santos Laguna [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 2. Round | 14/01/2023 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:6 | ||||
| 6. Round | 10/02/2023 | FC Juárez [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 8. Round | 18/02/2023 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 9. Round | 26/02/2023 | Santos Laguna [U20] | - | Puebla FC [U20] | 4:3 | ||||
| 10. Round | 04/03/2023 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 11. Round | 12/03/2023 | Santos Laguna [U20] | - | Club Tijuana [U20] | 1:3 | ||||
| 12. Round | 19/03/2023 | Club León [U20] | - | Santos Laguna [U20] | 1:3 | ||||
| 13. Round | 31/03/2023 | Club Necaxa [U20] | - | Santos Laguna [U20] | 0:2 |  |
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| 14. Round | 09/04/2023 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 16. Round | 23/04/2023 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 4:1 |
Mexico