| 1. Round | 23/07/2021 | Club Necaxa [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 2. Round | 01/08/2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 5. Round | 18/08/2021 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 7. Round | 29/08/2021 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:1 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 14. Round | 15/09/2021 | CF América [U20] | - | Santos Laguna [U20] | 0:1 |
Mexico