| 4. Round | 30/07/2022 | Mazatlán FC [Women] | - | CF América [Women] | 0:3 | ||||
| 5. Round | 02/08/2022 | CF América [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 6. Round | 09/08/2022 | Club León [Women] | - | CF América [Women] | 2:2 | ||||
| 7. Round | 11/08/2022 | CF América [Women] | - | Club Necaxa [Women] | 3:1 |  |
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| 9. Round | 24/08/2022 | CF América [Women] | - | Cruz Azul [Women] | 3:0 | |
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| 10. Round | 28/08/2022 | Club Tijuana [Women] | - | CF América [Women] | 1:3 |  |
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| 11. Round | 13/09/2022 | CF América [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 12. Round | 20/09/2022 | CF América [Women] | - | CF Monterrey [Women] | 1:2 | ||||
| 13. Round | 22/09/2022 | Atlético San Luis [Women] | - | CF América [Women] | 1:3 | ||||
| 14. Round | 27/09/2022 | CF América [Women] | - | CF Pachuca [Women] | 2:1 |  |
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| 16. Round | 17/10/2022 | CF América [Women] | - | Pumas UNAM [Women] | 6:1 | |
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| 17. Round | 21/10/2022 | Gallos Blancos [Women] | - | CF América [Women] | 0:1 | |
USA
Mexico