| 5. Round | 18/10/2020 | AFC Ajax | - | sc Heerenveen | 5:1 | ||||
| 6. Round | 24/10/2020 | VVV-Venlo | - | AFC Ajax | 0:13 | ||||
| 7. Round | 31/10/2020 | AFC Ajax | - | Fortuna Sittard | 5:2 | ||||
| 8. Round | 08/11/2020 | FC Utrecht | - | AFC Ajax | 0:3 | ||||
| 9. Round | 22/11/2020 | AFC Ajax | - | Heracles Almelo | 5:0 | ||||
| 10. Round | 28/11/2020 | FC Emmen | - | AFC Ajax | 0:5 |  |
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| 11. Round | 05/12/2020 | AFC Ajax | - | FC Twente | 1:2 | ||||
| 12. Round | 12/12/2020 | AFC Ajax | - | PEC Zwolle | 4:0 | ||||
| 13. Round | 20/12/2020 | ADO Den Haag | - | AFC Ajax | 2:4 | ||||
| 14. Round | 23/12/2020 | Willem II | - | AFC Ajax | 1:1 | ||||
| 26. Round | 14/03/2021 | PEC Zwolle | - | AFC Ajax | 0:2 | ||||
| 29. Round | 11/04/2021 | RKC Waalwijk | - | AFC Ajax | 0:1 | ||||
| 32. Round | 09/05/2021 | Feyenoord | - | AFC Ajax | 0:3 | ||||
| 33. Round | 13/05/2021 | AFC Ajax | - | VVV-Venlo | 3:1 | ||||
| 34. Round | 16/05/2021 | Vitesse | - | AFC Ajax | 1:3 |
Netherlands