| 5. Round | 08/08/2021 | Orange County SC | - | Los Angeles Galaxy II | 2:3 | ||||
| 5. Round | 15/08/2021 | Phoenix Rising | - | Orange County SC | 1:1 | ||||
| 5. Round | 19/08/2021 | Orange County SC | - | Tacoma Defiance | 0:3 | ||||
| 5. Round | 22/08/2021 | San Diego Loyal | - | Orange County SC | 1:2 |  |
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| 5. Round | 29/08/2021 | Charleston Battery | - | Orange County SC | 0:0 | ||||
| 6. Round | 04/09/2021 | Orange County SC | - | El Paso Locomotive | 2:2 |  |
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| 6. Round | 12/09/2021 | Orange County SC | - | Las Vegas Lights FC | 3:0 | ||||
| 6. Round | 19/09/2021 | Phoenix Rising | - | Orange County SC | 2:1 | ||||
| 6. Round | 26/09/2021 | Orange County SC | - | Oakland Roots | 2:1 | ||||
| 7. Round | 03/10/2021 | Orange County SC | - | Phoenix Rising | 0:1 | ||||
| 7. Round | 10/10/2021 | Tacoma Defiance | - | Orange County SC | 4:1 | ||||
| 7. Round | 14/10/2021 | Orange County SC | - | Phoenix Rising | 1:0 | ||||
| 7. Round | 17/10/2021 | Oakland Roots | - | Orange County SC | 0:1 | ||||
| 7. Round | 21/10/2021 | Orange County SC | - | San Diego Loyal | 1:0 | ||||
| 7. Round | 24/10/2021 | Orange County SC | - | Las Vegas Lights FC | 2:1 | ||||
| 7. Round | 31/10/2021 | Los Angeles Galaxy II | - | Orange County SC | 0:1 |
USA
Nigeria