| 2. Round | 10/06/2021 | Rocha | - | Central Español | 3:2 | ||||
| 3. Round | 20/06/2021 | Atenas | - | Rocha | 0:0 |  |
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| 4. Round | 25/06/2021 | Rocha | - | Racing | 2:3 | ||||
| 5. Round | 01/07/2021 | Villa Teresa | - | Rocha | 2:2 | ||||
| 6. Round | 08/07/2021 | Rocha | - | Juventud de Las Piedras | 2:1 |  |
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| 7. Round | 14/07/2021 | Uruguay Montevideo | - | Rocha | 2:1 | |
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| 8. Round | 22/07/2021 | Rocha | - | Rampla Juniors | 2:0 | ||||
| 9. Round | 29/07/2021 | Danubio | - | Rocha | 1:0 | ||||
| 10. Round | 04/08/2021 | Rocha | - | Albion | 0:2 | ||||
| 11. Round | 12/08/2021 | Rocha | - | CA Cerro | 1:3 | ||||
| 12. Round | 16/09/2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Round | 22/09/2021 | Central Español | - | Rocha | 1:0 | ||||
| 16. Round | 13/10/2021 | Rocha | - | Villa Teresa | 1:1 | ||||
| 20. Round | 10/11/2021 | Rocha | - | Danubio | 1:2 | ||||
| 21. Round | 18/11/2021 | Albion | - | Rocha | 0:1 | ||||
| 22. Round | 24/11/2021 | CA Cerro | - | Rocha | 3:0 |
Uruguay