| 1. Round | 15/02/2022 | Santa Cruz | - | Deportes Temuco | 1:1 |  |
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| 2. Round | 21/02/2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 5. Round | 14/03/2022 | Deportes Temuco | - | Fernández Vial | 1:1 |  |
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| 8. Round | 12/04/2022 | Rangers | - | Deportes Temuco | 3:2 | ||||
| 10. Round | 22/04/2022 | Unión San Felipe | - | Deportes Temuco | 0:0 | ||||
| 11. Round | 25/04/2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 | ||||
| 12. Round | 30/04/2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Round | 06/05/2022 | Deportes Temuco | - | Universidad de Concepción | 1:0 | ||||
| 14. Round | 11/05/2022 | Recoleta | - | Deportes Temuco | 2:1 | ||||
| 20. Round | 15/07/2022 | Deportes Temuco | - | Deportes Iquique | 3:2 | ||||
| 24. Round | 13/08/2022 | Santiago Morning | - | Deportes Temuco | 1:2 | |
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| 26. Round | 30/08/2022 | CD Magallanes | - | Deportes Temuco | 1:0 | ||||
| 33. Round | 24/10/2022 | Deportes Temuco | - | Barnechea | 4:1 |
Chile