| 1. Round | 14/07/2019 | San Lorenzo | - | Libertad | 0:1 | ||||
| 2. Round | 23/07/2019 | Sportivo Luqueño | - | San Lorenzo | 1:3 | ||||
| 9. Round | 15/09/2019 | Club Olimpia | - | San Lorenzo | 4:1 |  |
 |
||
| 10. Round | 21/09/2019 | San Lorenzo | - | Club Nacional | 0:3 | ||||
| 11. Round | 24/09/2019 | River Plate | - | San Lorenzo | 0:0 | ||||
| 13. Round | 08/10/2019 | San Lorenzo | - | Sportivo Luqueño | 2:0 | |
|
||
| 14. Round | 20/10/2019 | Cerro Porteño | - | San Lorenzo | 2:0 | ||||
| 15. Round | 27/10/2019 | San Lorenzo | - | Deportivo Santaní | 3:2 | |
|
||
| 16. Round | 31/10/2019 | Deportivo Capiatá | - | San Lorenzo | 1:1 | ||||
| 17. Round | 22/11/2019 | General Díaz | - | San Lorenzo | 1:1 |
Uruguay