| 5. Round | 16/03/2019 | Liverpool | - | Defensor Sporting | 6:2 | ||||
| 6. Round | 24/03/2019 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 7. Round | 31/03/2019 | Racing | - | Defensor Sporting | 4:2 | ||||
| 8. Round | 07/04/2019 | Defensor Sporting | - | Boston River | 0:0 | ||||
| 9. Round | 13/04/2019 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 10. Round | 21/04/2019 | Defensor Sporting | - | Plaza Colonia | 4:1 | ||||
| 11. Round | 05/05/2019 | CA Cerro | - | Defensor Sporting | 0:2 | ||||
| 12. Round | 11/05/2019 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 13. Round | 19/05/2019 | Nacional | - | Defensor Sporting | 1:0 | ||||
| 14. Round | 25/05/2019 | Defensor Sporting | - | Fénix | 2:4 | ||||
| 15. Round | 01/06/2019 | Progreso | - | Defensor Sporting | 0:3 |
Uruguay