| 1. Round | 08/01/2022 | Club Tijuana [U16] | - | Club León [U16] | 2:2 | ||||
| 2. Round | 15/01/2022 | Club León [U16] | - | UANL Tigres [U16] | 0:1 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 | ||||
| 5. Round | 05/02/2022 | CF Monterrey [U16] | - | Club León [U16] | 0:1 | ||||
| 6. Round | 12/02/2022 | Club León [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
| 8. Round | 26/02/2022 | Atlas Guadalajara [U16] | - | Club León [U16] | 5:0 | ||||
| 9. Round | 05/03/2022 | Club León [U16] | - | Mazatlán FC [U16] | 4:0 | ||||
| 13. Round | 02/04/2022 | Mazatlán FC [U16] | - | Club León [U16] | 2:3 | ||||
| 15. Round | 16/04/2022 | Atlético San Luis [U16] | - | Club León [U16] | 1:3 | ||||
| 16. Round | 23/04/2022 | Club León [U16] | - | Club Tijuana [U16] | 1:0 | ||||
| 17. Round | 30/04/2022 | Club León [U16] | - | CF Monterrey [U16] | 1:2 | ||||
| 18. Round | 07/05/2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico