| 1. Round | 09/01/2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 0:0 |  |
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| 3. Round | 22/01/2022 | Atlas Guadalajara [U16] | - | CF Monterrey [U16] | 2:2 | |
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| 4. Round | 29/01/2022 | CF Monterrey [U16] | - | Mazatlán FC [U16] | 2:2 | ||||
| 5. Round | 05/02/2022 | CF Monterrey [U16] | - | Club León [U16] | 0:1 | |
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| 7. Round | 19/02/2022 | Club Tijuana [U16] | - | CF Monterrey [U16] | 1:0 | ||||
| 10. Round | 12/03/2022 | Mazatlán FC [U16] | - | CF Monterrey [U16] | 2:3 | ||||
| 11. Round | 19/03/2022 | CF Monterrey [U16] | - | Atlas Guadalajara [U16] | 1:1 | ||||
| 12. Round | 26/03/2022 | Atlético San Luis [U16] | - | CF Monterrey [U16] | 1:1 | ||||
| 15. Round | 30/03/2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 5:1 | ||||
| 13. Round | 02/04/2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 14. Round | 27/04/2022 | CF Monterrey [U16] | - | UANL Tigres [U16] | 2:3 | ||||
| 17. Round | 30/04/2022 | Club León [U16] | - | CF Monterrey [U16] | 1:2 | ||||
| 18. Round | 07/05/2022 | CF Monterrey [U16] | - | Club Tijuana [U16] | 3:1 |
USA
Mexico