| Round of 16 | 17/02/2022 | Forge FC | - | Cruz Azul | 0:1 | ||||
| Round of 16 | 25/02/2022 | Cruz Azul | - | Forge FC | 3:1 | ||||
| Quarter-finals | 17/03/2022 | CF Montréal | - | Cruz Azul | 1:1 |  |
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| Semi-finals | 06/04/2022 | Pumas UNAM | - | Cruz Azul | 2:1 | ||||
| Semi-finals | 13/04/2022 | Cruz Azul | - | Pumas UNAM | 0:0 |
Mexico