| 1. Round | 16/08/2008 | SV Darmstadt 98 | - | Karlsruher SC II | 1:4 | ||||
| 2. Round | 24/08/2008 | Karlsruher SC II | - | SV Wehen Wiesbaden II | 0:1 | ||||
| 3. Round | 31/08/2008 | SpVgg Unterhaching II | - | Karlsruher SC II | 2:2 |  |
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| 4. Round | 13/09/2008 | Karlsruher SC II | - | Viktoria Aschaffenburg | 1:3 | |
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| 5. Round | 21/09/2008 | Karlsruher SC II | - | 1. FC Nürnberg II | 1:1 |  |
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| 6. Round | 27/09/2008 | SC Pfullendorf | - | Karlsruher SC II | 3:2 | |
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| 7. Round | 05/10/2008 | Karlsruher SC II | - | SSV Ulm 1846 | 1:1 | ||||
| 8. Round | 18/10/2008 | 1. FC Eintracht Bamberg | - | Karlsruher SC II | 2:0 | ||||
| 9. Round | 25/10/2008 | Karlsruher SC II | - | TSV 1860 München II | 1:3 | |
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| 10. Round | 29/10/2008 | Hessen Kassel | - | Karlsruher SC II | 0:1 | ||||
| 11. Round | 02/11/2008 | Karlsruher SC II | - | SC Freiburg II | 0:0 | ||||
| 12. Round | 08/11/2008 | SpVgg Greuther Fürth II | - | Karlsruher SC II | 1:2 | ||||
| 13. Round | 15/11/2008 | Karlsruher SC II | - | Waldhof Mannheim | 2:1 | |
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| 15. Round | 30/11/2008 | Karlsruher SC II | - | SSV Reutlingen | 2:1 | ||||
| 18. Round | 20/12/2008 | Karlsruher SC II | - | SV Darmstadt 98 | 0:2 | ||||
| 30. Round | 13/05/2009 | Waldhof Mannheim | - | Karlsruher SC II | 3:0 | |
Germany