| 2. Round | 16/01/2021 | Cruz Azul [U17] | - | Puebla FC [U17] | 2:1 | ||||
| 3. Round | 22/01/2021 | Puebla FC [U17] | - | Club Tijuana [U17] | 1:3 | ||||
| 5. Round | 06/02/2021 | CF América [U17] | - | Puebla FC [U17] | 1:2 | ||||
| 6. Round | 12/02/2021 | Puebla FC [U17] | - | FC Juárez [U17] | 1:2 | ||||
| 7. Round | 21/02/2021 | Gallos Blancos [U17] | - | Puebla FC [U17] | 1:2 | ||||
| 9. Round | 02/03/2021 | Club León [U17] | - | Puebla FC [U17] | 4:3 | ||||
| 10. Round | 05/03/2021 | Puebla FC [U17] | - | UANL Tigres [U17] | 2:2 | ||||
| 11. Round | 12/03/2021 | Puebla FC [U17] | - | Atlas Guadalajara [U17] | 2:0 | ||||
| 1. Round | 27/03/2021 | Puebla FC [U17] | - | Deportivo Guadalajara [U17] | 0:0 | ||||
| 13. Round | 02/04/2021 | Puebla FC [U17] | - | Mazatlán FC [U17] | 3:0 | ||||
| 4. Round | 07/04/2021 | Puebla FC [U17] | - | CF Monterrey [U17] | 2:3 | ||||
| 15. Round | 17/04/2021 | Atlético San Luis [U17] | - | Puebla FC [U17] | 2:1 | ||||
| 16. Round | 23/04/2021 | Puebla FC [U17] | - | Pumas UNAM [U17] | 2:8 | ||||
| 17. Round | 02/05/2021 | Santos Laguna [U17] | - | Puebla FC [U17] | 1:0 |  |
Mexico