| 3. Round | 26/04/2021 | Santiago Morning | - | Santa Cruz | 1:3 | ||||
| 21. Round | 24/09/2021 | Coquimbo Unido | - | Santa Cruz | 0:0 |  |
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| 22. Round | 28/09/2021 | Santa Cruz | - | Unión San Felipe | 0:1 | ||||
| 24. Round | 08/10/2021 | Santa Cruz | - | Deportes Copiapó | 1:2 | |
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| 25. Round | 12/10/2021 | San Luis | - | Santa Cruz | 0:0 |
Chile