| 2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Round | 25/01/2021 | Gallos Blancos | - | Pumas UNAM | 2:0 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM | - | CF Pachuca | 2:2 |  |
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| 14. Round | 10/04/2021 | Club Necaxa | - | Pumas UNAM | 0:1 | ||||
| 15. Round | 18/04/2021 | Pumas UNAM | - | UANL Tigres | 0:0 | ||||
| 16. Round | 24/04/2021 | Puebla FC | - | Pumas UNAM | 0:0 | ||||
| 17. Round | 03/05/2021 | Pumas UNAM | - | CF América | 0:1 |
USA
Mexico