| 1. Round | 11/02/2022 | Vélez Sarsfield | - | Aldosivi | 2:0 | ||||
| 2. Round | 15/02/2022 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Round | 20/02/2022 | Vélez Sarsfield | - | Independiente | 0:0 | ||||
| 4. Round | 25/02/2022 | Huracán | - | Vélez Sarsfield | 2:0 | ||||
| 7. Round | 22/03/2022 | Argentinos Juniors | - | Vélez Sarsfield | 1:0 | ||||
| 9. Round | 10/04/2022 | Vélez Sarsfield | - | Boca Juniors | 0:0 | ||||
| 12. Round | 24/04/2022 | Barracas Central | - | Vélez Sarsfield | 1:1 | ||||
| 13. Round | 30/04/2022 | Vélez Sarsfield | - | Tigre | 3:2 |  |
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| 14. Round | 09/05/2022 | Colón de Santa Fe | - | Vélez Sarsfield | 1:2 | |
Uruguay