| 2. Round | 11/09/2021 | Almere City FC [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 3. Round | 18/09/2021 | FC Groningen [U21] | - | Feyenoord [U21] | 2:1 | ||||
| 4. Round | 25/09/2021 | sc Heerenveen [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 5. Round | 02/10/2021 | FC Groningen [U21] | - | NAC Breda [U21] | 1:2 | ||||
| 6. Round | 16/10/2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 7. Round | 23/10/2021 | FC Groningen [U21] | - | ADO Den Haag [U21] | 2:1 | ||||
| 8. Round | 30/10/2021 | NAC Breda [U21] | - | FC Groningen [U21] | 0:2 |  |
|||
| 10. Round | 20/11/2021 | ADO Den Haag [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 11. Round | 27/11/2021 | FC Groningen [U21] | - | Almere City FC [U21] | 3:0 | ||||
| 9. Round | 30/11/2021 | FC Groningen [U21] | - | sc Heerenveen [U21] | 3:2 | |
 |
||
| 13. Round | 26/02/2022 | Feyenoord [U21] | - | FC Groningen [U21] | 1:0 |
Norway