| 1. Round | 03/07/2022 | Pumas UNAM [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 2. Round | 08/07/2022 | Club Tijuana [U20] | - | FC Juárez [U20] | 1:1 | ||||
| 4. Round | 23/07/2022 | Club Tijuana [U20] | - | CF América [U20] | 3:3 |  |
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| 5. Round | 26/07/2022 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 4:1 | ||||
| 6. Round | 30/07/2022 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 7. Round | 07/08/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 2:2 | |
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| 9. Round | 17/08/2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 |  |
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| 16. Round | 25/08/2022 | Club Tijuana [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 11. Round | 28/08/2022 | Club Tijuana [U20] | - | CF Monterrey [U20] | 1:1 | |
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| 12. Round | 01/09/2022 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:2 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 14. Round | 11/09/2022 | CF Pachuca [U20] | - | Club Tijuana [U20] | 4:0 | ||||
| 3. Round | 28/09/2022 | UANL Tigres [U20] | - | Club Tijuana [U20] | 3:0 | ||||
| 17. Round | 02/10/2022 | Club León [U20] | - | Club Tijuana [U20] | 1:0 |
Mexico