| 9. Round | 17/04/2022 | CD Guabirá | - | Club Aurora | 3:2 | ||||
| 10. Round | 20/04/2022 | Club Aurora | - | Oriente Petrolero | 1:1 | ||||
| 11. Round | 24/04/2022 | Atlético Palmaflor | - | Club Aurora | 0:1 | ||||
| 12. Round | 30/04/2022 | Club Aurora | - | Universitario de Sucre | 3:0 | ||||
| 13. Round | 08/05/2022 | Jorge Wilstermann | - | Club Aurora | 0:0 | ||||
| 14. Round | 12/05/2022 | Club Aurora | - | Real Santa Cruz | 2:4 | ||||
| 15. Round | 15/05/2022 | Club Aurora | - | Nacional Potosí | 2:3 |  |
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| 16. Round | 21/05/2022 | The Strongest | - | Club Aurora | 1:0 |
Paraguay