| Group C | 15/09/2021 | Sporting CP | - | AFC Ajax | 1:5 |  |
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| Group C | 28/09/2021 | AFC Ajax | - | Beşiktaş | 2:0 | |
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| Group C | 19/10/2021 | AFC Ajax | - | Borussia Dortmund | 4:0 | |
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| Group C | 03/11/2021 | Borussia Dortmund | - | AFC Ajax | 1:3 | |
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| Group C | 24/11/2021 | Beşiktaş | - | AFC Ajax | 1:2 | |
 |
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| Group C | 07/12/2021 | AFC Ajax | - | Sporting CP | 4:2 | |
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| Round of 16 | 23/02/2022 | SL Benfica | - | AFC Ajax | 2:2 | |
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| Round of 16 | 15/03/2022 | AFC Ajax | - | SL Benfica | 0:1 |
France
