| 15. Round | 10/01/2021 | AFC Ajax | - | PSV Eindhoven | 2:2 | ||||
| 16. Round | 14/01/2021 | FC Twente | - | AFC Ajax | 1:3 |  |
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| 17. Round | 17/01/2021 | AFC Ajax | - | Feyenoord | 1:0 | ||||
| 18. Round | 24/01/2021 | Fortuna Sittard | - | AFC Ajax | 1:2 | |
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| 19. Round | 28/01/2021 | AFC Ajax | - | Willem II | 3:1 | ||||
| 20. Round | 31/01/2021 | AZ Alkmaar | - | AFC Ajax | 0:3 | ||||
| 22. Round | 13/02/2021 | Heracles Almelo | - | AFC Ajax | 0:2 | |
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| 23. Round | 21/02/2021 | AFC Ajax | - | Sparta Rotterdam | 4:2 | |
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| 24. Round | 28/02/2021 | PSV Eindhoven | - | AFC Ajax | 1:1 | ||||
| 25. Round | 07/03/2021 | AFC Ajax | - | FC Groningen | 3:1 | |
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| 26. Round | 14/03/2021 | PEC Zwolle | - | AFC Ajax | 0:2 | |
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| 28. Round | 04/04/2021 | sc Heerenveen | - | AFC Ajax | 1:2 | |
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| 29. Round | 11/04/2021 | RKC Waalwijk | - | AFC Ajax | 0:1 | |
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| 21. Round | 22/04/2021 | AFC Ajax | - | FC Utrecht | 1:1 | ||||
| 30. Round | 25/04/2021 | AFC Ajax | - | AZ Alkmaar | 2:0 | ||||
| 31. Round | 02/05/2021 | AFC Ajax | - | FC Emmen | 4:0 | |
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| 32. Round | 09/05/2021 | Feyenoord | - | AFC Ajax | 0:3 | ||||
| 33. Round | 13/05/2021 | AFC Ajax | - | VVV-Venlo | 3:1 | |
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| 34. Round | 16/05/2021 | Vitesse | - | AFC Ajax | 1:3 | |
France
