| 2. Round | 13/08/2021 | Helmond Sport | - | AZ Alkmaar (J) | 1:2 | ||||
| 4. Round | 27/08/2021 | VVV-Venlo | - | AZ Alkmaar (J) | 0:1 |  |
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| 6. Round | 10/09/2021 | AZ Alkmaar (J) | - | FC Utrecht (J) | 0:1 | ||||
| 7. Round | 17/09/2021 | FC Den Bosch | - | AZ Alkmaar (J) | 2:1 | ||||
| 8. Round | 24/09/2021 | Telstar | - | AZ Alkmaar (J) | 1:0 | ||||
| 11. Round | 15/10/2021 | NAC Breda | - | AZ Alkmaar (J) | 1:0 | ||||
| 16. Round | 19/11/2021 | Roda JC Kerkrade | - | AZ Alkmaar (J) | 2:2 | ||||
| 17. Round | 26/11/2021 | FC Eindhoven | - | AZ Alkmaar (J) | 1:0 | ||||
| 19. Round | 10/12/2021 | ADO Den Haag | - | AZ Alkmaar (J) | 3:2 | ||||
| 26. Round | 11/02/2022 | FC Volendam | - | AZ Alkmaar (J) | 2:1 | ||||
| 28. Round | 25/02/2022 | AZ Alkmaar (J) | - | FC Eindhoven | 1:3 | |
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| 29. Round | 04/03/2022 | De Graafschap | - | AZ Alkmaar (J) | 0:0 | ||||
| 27. Round | 14/03/2022 | MVV | - | AZ Alkmaar (J) | 2:3 | ||||
| 34. Round | 08/04/2022 | FC Emmen | - | AZ Alkmaar (J) | 3:0 | ||||
| 35. Round | 15/04/2022 | AZ Alkmaar (J) | - | ADO Den Haag | 0:1 | ||||
| 37. Round | 29/04/2022 | AZ Alkmaar (J) | - | Helmond Sport | 0:1 |
Spain