| 4. Round | 14/08/2021 | SShOR Zenit [Youth] | - | Lokomotiv Moskva [Youth] | 4:1 |  |
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| 5. Round | 21/08/2021 | Rubin Kazan [Youth] | - | Lokomotiv Moskva [Youth] | 1:2 | ||||
| 6. Round | 25/08/2021 | FShM Moskva [Youth] | - | Lokomotiv Moskva [Youth] | 0:2 | ||||
| 7. Round | 13/09/2021 | Lokomotiv Moskva [Youth] | - | Zenit St. Petersburg [Youth] | 2:3 | ||||
| 8. Round | 18/09/2021 | FK Krasnodar [Youth] | - | Lokomotiv Moskva [Youth] | 3:1 | |
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| 9. Round | 25/09/2021 | Lokomotiv Moskva [Youth] | - | FK Saturn [Youth] | 5:0 | ||||
| 10. Round | 02/10/2021 | Spartak Moskva [Youth] | - | Lokomotiv Moskva [Youth] | 3:1 | ||||
| 11. Round | 16/10/2021 | Lokomotiv Moskva [Youth] | - | Dinamo Moskva [Youth] | 4:1 | ||||
| 12. Round | 23/10/2021 | Lokomotiv Moskva [Youth] | - | Kuban Krasnodar [Youth] | 2:2 | |
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| 16. Round | 27/11/2021 | FK Rostov [Youth] | - | Lokomotiv Moskva [Youth] | 0:0 | |
Russia