| 1. Round | 22/02/2025 | Los Angeles FC | - | Minnesota United FC | 1:0 | ||||
| 2. Round | 02/03/2025 | Los Angeles FC | - | New York City FC | 1:0 | ||||
| 3. Round | 08/03/2025 | Seattle Sounders | - | Los Angeles FC | 5:2 | ||||
| 4. Round | 15/03/2025 | Los Angeles FC | - | Austin FC | 0:1 | ||||
| 5. Round | 23/03/2025 | Sporting Kansas City | - | Los Angeles FC | 0:2 |  |
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| 6. Round | 30/03/2025 | San Diego FC | - | Los Angeles FC | 3:2 | ||||
| 7. Round | 06/04/2025 | Houston Dynamo | - | Los Angeles FC | 1:0 | ||||
| 8. Round | 13/04/2025 | Los Angeles FC | - | San Jose Earthquakes | 2:1 |  |
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| 9. Round | 20/04/2025 | Portland Timbers | - | Los Angeles FC | 3:3 | |
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| 10. Round | 28/04/2025 | Los Angeles FC | - | St. Louis City SC | 2:2 | ||||
| 11. Round | 04/05/2025 | Los Angeles FC | - | Houston Dynamo | 2:0 | ||||
| 12. Round | 12/05/2025 | Vancouver Whitecaps | - | Los Angeles FC | 2:2 | |
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| 13. Round | 15/05/2025 | Los Angeles FC | - | Seattle Sounders | 4:0 | ||||
| 14. Round | 19/05/2025 | Los Angeles Galaxy | - | Los Angeles FC | 2:2 | |
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| 15. Round | 25/05/2025 | CF Montréal | - | Los Angeles FC | 2:2 |
Spain