| 3. Round | 07/08/2021 | Club Necaxa | - | Cruz Azul | 1:2 | ||||
| 8. Round | 13/09/2021 | Gallos Blancos | - | Club Necaxa | 3:0 | ||||
| 9. Round | 18/09/2021 | Club Necaxa | - | Atlas Guadalajara | 0:3 | ||||
| 10. Round | 24/09/2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
| 12. Round | 04/10/2021 | UANL Tigres | - | Club Necaxa | 0:0 | ||||
| 13. Round | 16/10/2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 14. Round | 21/10/2021 | Deportivo Toluca | - | Club Necaxa | 1:1 |
Paraguay