2. Round | 13/02/2022 | Guaraní | - | Sol de América | 0:1 | ||||
3. Round | 19/02/2022 | Cerro Porteño | - | Guaraní | 2:0 | ||||
4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
9. Round | 10/04/2022 | Sportivo Ameliano | - | Guaraní | 0:1 | ||||
11. Round | 20/04/2022 | Club Olimpia | - | Guaraní | 1:0 | ||||
12. Round | 25/04/2022 | Guaraní | - | Guaireña FC | 2:1 | ||||
13. Round | 01/05/2022 | Sol de América | - | Guaraní | 2:2 | ||||
18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 |