| 1. Round | 11/01/2025 | Colima FC | - | Sporting Canamy | 2:1 |  |
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| 2. Round | 19/01/2025 | Club Irapuato | - | Colima FC | 6:0 |  |
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| 3. Round | 25/01/2025 | Colima FC | - | Lobos ULMX | 1:0 | ||||
| 4. Round | 02/02/2025 | Gavilanes de Matamoros | - | Colima FC | 6:1 | ||||
| 5. Round | 08/02/2025 | Colima FC | - | Aguacateros de Peribán | 0:4 | |
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| 6. Round | 15/02/2025 | Club Zacatepec | - | Colima FC | 2:0 | ||||
| 7. Round | 22/02/2025 | Colima FC | - | Halcones FC | 0:3 | |
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| 8. Round | 01/03/2025 | Petroleros de Salamanca | - | Colima FC | 0:1 | ||||
| 9. Round | 08/03/2025 | Colima FC | - | Reboceros de La Piedad | 2:1 | |
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| 10. Round | 15/03/2025 | Aguacateros CDU | - | Colima FC | 2:0 | |
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| 12. Round | 29/03/2025 | Colima FC | - | Los Cabos United | 0:0 | ||||
| 13. Round | 05/04/2025 | Leones Negros II | - | Colima FC | 2:0 | |
Mexico