| 1. Round | 22/08/2010 | El Tanque Sisley | - | Racing | 1:0 |  |
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| 2. Round | 29/08/2010 | Tacuarembó | - | El Tanque Sisley | 1:2 | ||||
| 3. Round | 04/09/2010 | El Tanque Sisley | - | Nacional | 1:1 | ||||
| 4. Round | 18/09/2010 | Peñarol | - | El Tanque Sisley | 0:0 | ||||
| 6. Round | 03/10/2010 | Central Español | - | El Tanque Sisley | 3:5 | ||||
| 7. Round | 10/10/2010 | El Tanque Sisley | - | Rampla Juniors | 3:2 | ||||
| 5. Round | 12/10/2010 | Defensor Sporting | - | El Tanque Sisley | 3:1 | ||||
| 8. Round | 17/10/2010 | El Tanque Sisley | - | Montevideo Wanderers | 1:1 | ||||
| 9. Round | 24/10/2010 | Bella Vista | - | El Tanque Sisley | 1:2 | ||||
| 10. Round | 31/10/2010 | Danubio | - | El Tanque Sisley | 2:0 | ||||
| 11. Round | 07/11/2010 | El Tanque Sisley | - | Liverpool | 1:1 | ||||
| 12. Round | 14/11/2010 | River Plate | - | El Tanque Sisley | 1:2 | |
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| 13. Round | 21/11/2010 | El Tanque Sisley | - | CA Cerro | 0:2 | ||||
| 14. Round | 28/11/2010 | Miramar Misiones | - | El Tanque Sisley | 0:1 | ||||
| 15. Round | 05/12/2010 | Fénix | - | El Tanque Sisley | 0:1 | |
Uruguay