| 1. Round | 09/01/2021 | CF América [U20] | - | Atlético San Luis [U20] | 4:1 | ||||
| 2. Round | 16/01/2021 | CF Monterrey [U20] | - | CF América [U20] | 2:1 | ||||
| 3. Round | 27/01/2021 | CF América [U20] | - | FC Juárez [U20] | 1:1 | ||||
| 4. Round | 31/01/2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 |  |
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| 5. Round | 06/02/2021 | CF América [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 6. Round | 13/02/2021 | CF América [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 7. Round | 20/02/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 2:1 | ||||
| 8. Round | 27/02/2021 | CF América [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 9. Round | 03/03/2021 | Club Tijuana [U20] | - | CF América [U20] | 0:1 | ||||
| 10. Round | 06/03/2021 | CF América [U20] | - | Club León [U20] | 0:1 | ||||
| 11. Round | 14/03/2021 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | ||||
| 12. Round | 19/03/2021 | Mazatlán FC [U20] | - | CF América [U20] | 1:0 | ||||
| 17. Round | 01/05/2021 | Pumas UNAM [U20] | - | CF América [U20] | 0:1 |
Mexico