| 5. Round | 17/08/2020 | Gallos Blancos | - | CF América | 4:1 | ||||
| 6. Round | 23/08/2020 | CF América | - | CF Monterrey | 1:3 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 14. Round | 20/10/2020 | Club León | - | CF América | 3:2 | ||||
| 16. Round | 01/11/2020 | CF América | - | UANL Tigres | 3:1 | ||||
| 17. Round | 07/11/2020 | FC Juárez | - | CF América | 1:1 |
Paraguay