| 2. Round | 03/09/2016 | Sud América | - | Villa Española | 1:0 |  |
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| 3. Round | 11/09/2016 | Danubio | - | Villa Española | 1:0 | ||||
| 4. Round | 18/09/2016 | Villa Española | - | Plaza Colonia | 2:4 | ||||
| 5. Round | 24/09/2016 | Liverpool | - | Villa Española | 1:0 | |
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| 6. Round | 02/10/2016 | Villa Española | - | Nacional | 0:1 | ||||
| 7. Round | 09/10/2016 | Villa Española | - | Racing | 1:1 | ||||
| 8. Round | 15/10/2016 | Peñarol | - | Villa Española | 2:1 | |
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| 9. Round | 22/10/2016 | Villa Española | - | CA Cerro | 2:0 |  |
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| 11. Round | 12/11/2016 | Villa Española | - | Defensor Sporting | 2:2 | |
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| 12. Round | 19/11/2016 | Villa Española | - | Boston River | 0:3 | ||||
| 13. Round | 26/11/2016 | River Plate | - | Villa Española | 2:1 | ||||
| 14. Round | 04/12/2016 | Montevideo Wanderers | - | Villa Española | 3:1 | ||||
| 15. Round | 10/12/2016 | Villa Española | - | Fénix | 2:2 | |
Uruguay