16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
19. Round | 18/06/2022 | Sportivo Ameliano | - | Club Nacional | 2:2 | ||||
21. Round | 26/06/2022 | Club Nacional | - | Guaraní | 0:1 | ||||
22. Round | 01/07/2022 | Guaireña FC | - | Club Nacional | 1:1 |