| 1. Round | 12/07/2015 | Santa Fe | - | La Equidad | 4:0 | ||||
| 2. Round | 20/07/2015 | Santa Fe | - | Cúcuta Deportivo | 5:0 | ||||
| 3. Round | 25/07/2015 | Boyacá Chicó | - | Santa Fe | 0:1 | ||||
| 4. Round | 02/08/2015 | Santa Fe | - | Alianza Petrolera | 1:1 | ||||
| 6. Round | 15/08/2015 | Independiente Medellín | - | Santa Fe | 1:1 |  |
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| 8. Round | 23/08/2015 | Santa Fe | - | Atlético Huila | 2:1 | ||||
| 10. Round | 06/09/2015 | Santa Fe | - | Millonarios | 1:1 | |
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| 11. Round | 10/09/2015 | Uniautónoma FC | - | Santa Fe | 0:1 | ||||
| 14. Round | 27/09/2015 | Deportes Tolima | - | Santa Fe | 1:0 |
Colombia