| 1. Round | 11/01/2003 | Deportivo Guadalajara | - | Puebla FC | 2:1 |  |
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| 7. Round | 22/02/2003 | Pumas UNAM | - | Puebla FC | 1:0 | ||||
| 9. Round | 07/03/2003 | CF Monterrey | - | Puebla FC | 0:0 | ||||
| 10. Round | 15/03/2003 | Puebla FC | - | Deportivo Toluca | 3:1 |  |
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| 11. Round | 21/03/2003 | Atlas Guadalajara | - | Puebla FC | 2:0 | ||||
| 13. Round | 05/04/2003 | Puebla FC | - | Atlético Cuernavaca | 0:1 | ||||
| 14. Round | 12/04/2003 | CF América | - | Puebla FC | 0:1 | |
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| 15. Round | 19/04/2003 | Puebla FC | - | Jaguares Chiapas | 3:2 | |
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| 16. Round | 25/04/2003 | Cruz Azul | - | Puebla FC | 4:0 | |
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| 17. Round | 02/05/2003 | Puebla FC | - | UAG Tecos | 2:2 | |
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| 18. Round | 09/05/2003 | UANL Tigres | - | Puebla FC | 1:0 | ||||
| 19. Round | 16/05/2003 | Puebla FC | - | CF Pachuca | 1:1 | |
Uruguay