| 3. Round | 29/01/2022 | Inter de Querétaro | - | Escorpiones | 0:2 | ||||
| 5. Round | 12/02/2022 | Inter de Querétaro | - | CD Zap | 0:3 | ||||
| 6. Round | 18/02/2022 | Inter Playa | - | Inter de Querétaro | 3:0 |  |
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| 7. Round | 27/02/2022 | Montañeses FC | - | Inter de Querétaro | 1:2 | ||||
| 8. Round | 05/03/2022 | Inter de Querétaro | - | Leviatán FC | 2:2 | ||||
| 10. Round | 19/03/2022 | Inter de Querétaro | - | Yalmakan FC | 0:2 |
Mexico